Toxicology International (Formerly Indian Journal of Toxicology)

Karan Devasani ¹, Rema Razdan ¹, K. Chaithanya ¹, Rituvivek Kimbahune ²

Affiliations
1 Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, IN
2 Department of Quality Assurance, Al-Ameen College of Pharmacy, Bangalore, IN

Abstract

Today there is an upsurge in the public and media concern about the potential health risk of radiofrequency field exposure. Interaction of radio frequency electromagnetic radiation with the brain is a precarious apprehension in our society. The current study was aimed to evaluate the possible implications on neurotransmitter and AChE activity levels on exposure to radio frequency-electromagnetic radiation (RF-EMR) in male rats at 900 MHz and 1800 MHz frequencies for 2 h per day for 3 months. Wistar rats were categorised into three groups (n=6) viz., sham exposure, exposure to 1800 MHz and exposure to 900 MHz. At the end of the study alterations in neurotransmitters level and histopathology of brain were analysed. The brain level of dopamine, nor-adrenaline, GABA and AChE enzyme activity was found to be significantly lowered. Histopathological findings of brain showed a marked congestion of the cerebral blood vessels and few of the pyramidal cells and neuroglial cells show degenerative changes with mild inflammatory infiltration. Thus, our results suggest that exposure to RF-EMR certainly causesinhibition of AChE activity, alteration in brain transmitter levels and changes in the architecture of brain parenchymal tissue.

Keywords

RF-EMR, Dopamine, Nor-Adrenaline, GABA, Acetylcholinesterase Enzyme.

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Karan Devasani ¹, Rema Razdan ¹

Affiliations
1 Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, IN

Abstract

Today there is an unprecedented growth of wireless technology and upsurge in the public about potential health risk factors. Communication using cell phone in a pool of radio frequency electromagnetic radiation is a precarious apprehension in our society. Effect on blood pressure and blood profile is one of the utmost area of research interest. The current study was aimed to evaluate the possible implications on blood pressure and haematological parameters on chronic exposure to radio frequency electromagnetic radiation (RF-EMR) in male and female wistar rats at 900 MHz and 1800 MHz frequencies for 2 h per day for 3 months. In this study 36 rats were evenly categorised into 3 groups, each group consists of male and female rats: group 1 (sham exposed); group 2 (1800 MHz (exposed); group 3 (900 MHz exposed). Non-invasive blood pressure was recorded using tail cuff and haematological parameters was measured at the end of experiment. In our study, results obtained did not showed any significant differences in the haemoglobin (%), RBC count, Total W.B.C count, eosinophils (%) when compared to sham exposed rats. Surprisingly, male and female rats exposed to 900 MHz was found to be decrease in their blood pressure while male and female rats exposed to 1800 MHz was not found to be significant difference as compared to sham exposed. Whereas platelet count was found to be significantly increased in male rats exposed to 1800 MHz and 900 MHz. According to our perspective there has been no conclusive evidence that using a mobile phone could bring changes in BP and haematology.

Keywords

RF-EMR, Blood Pressure, Haematology, 900 MHz and 1800 MHz.

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